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Uncontrolled eczema can
come and go without warning

Atopic dermatitis is the most common type of eczema, affecting over 16 million
adults in the United States.

Explore symptoms

Chronic inflammation
underneath the surface

Normal skin and eczema skin comparison example.

Chronic inflammation
underneath the surface

Eczema is a chronic skin disease that’s caused by an overactive immune response. When the immune response is triggered, it causes inflammation, and your skin can become itchy, red, and dry.

With eczema, the overactive immune response causes inflammation. So even when symptoms aren’t present on your skin, inflammation can still be happening under your skin.

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How IL-13 triggers eczema inflammation

While the exact cause of eczema is unknown, we do know that people with eczema have an overactive immune response and a weakened skin barrier that causes damage to the skin. That overactive immune response produces a number of proteins in the body—one of which is IL-13 (interleukin-13). IL-13 is a protein that sends signals that lead to inflammation in the skin.

Studies have shown that people with eczema have more IL-13 in their skin than people without eczema. It’s also been shown that the more IL-13 people have, the more severe their eczema.

The itch-scratch cycle

When too much IL-13 is present in the skin, it leads to continued inflammation and unbearable itch. When you scratch your skin, the skin barrier weakens and becomes more damaged, allowing substances such as bacteria, allergens, and viruses to enter.

When the immune system detects these substances, the body produces more IL-13 in the skin, starting the vicious cycle again.

The itch-scratch cycle

The cycle of inflammation, scratch, and itch related to eczema.

For illustrative purposes.
Actor portrayal.

What can moderate-to-severe eczema look like?*

Dry or scaly skin due to moderate-to-severe eczema.

Dry or scaly skin

Darkening of the skin due to moderate-to-severe eczema.

Darkening of the skin

Itching due to moderate-to-severe eczema.

Itching

Thickening of skin due to moderate-to-severe eczema.

Thickening of the skin

Reddening of the skin due to moderate-to-severe eczema.

Reddening of the skin

Small raised bumps on skin due to moderate-to-severe eczema.

Small raised bumps

Moderate-to-severe eczema can appear at different times on different body parts. Eczema most commonly appears on the neck, hands, arms, back of the knees, and inside of the elbows. The photos above do not show all possible symptoms.

*Images show common symptoms of moderate-to-severe atopic dermatitis (eczema) and may not represent all possible symptoms, which can appear at different times.

Patient video of Tayttum, a real Adbry® patient.

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Individual results may vary.

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How Adbry® can help

Clearer skin and
itch control is possible.

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INDICATION

What is ADBRY?

  • ADBRY injection is a prescription medicine used to treat people 12 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. ADBRY can be used with or without topical corticosteroids.
  • It is not known if ADBRY is safe and effective in children under 12 years of age.

Please see full Prescribing Information, including Patient Information and Instructions for Use.

IMPORTANT SAFETY INFORMATION AND INDICATION

IMPORTANT SAFETY INFORMATION

  • Do not use ADBRY if you are allergic to tralokinumab or to any of its ingredients.
  • Before you start ADBRY, make sure you talk with your healthcare provider about the medicines you take and all your medical conditions, especially if you have any eye problems, or if you have a parasitic (helminth) infection.
  • Also tell your provider if you’re scheduled to receive any vaccinations. If you’re treated with ADBRY, you should not receive a “live vaccine.”
  • Talk to your healthcare provider if you are or planning to be pregnant or breastfeed. There is a pregnancy exposure registry for women who use ADBRY during pregnancy. The purpose of this registry is to collect information about the health of you and your baby.
  • Serious side effects can include allergic reactions, including a severe reaction known as anaphylaxis.
  • Stop using ADBRY and tell your healthcare provider or get emergency help right away if you have breathing problems, itching, rash, swelling of the face, mouth, or tongue, fainting, dizziness, feeling lightheaded or hives.
  • ADBRY can also cause eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.
  • Common side effects include upper respiratory tract infections, eye and eyelid inflammation, injection site reactions, and a high count of a certain white blood cell.

These are not all the possible side effects of ADBRY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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